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Description for Protein CBX3

chromobox homolog 3
31 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CHROMO: Chromatin organization modifier domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11586
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    HP1Hs-gamma; HP1-GAMMA; Chromobox homolog 3 (HP1 gamma homolog); Heterochromatin-like protein 1; Heterochromatin protein HP1 gamma; Modifier 2 protein; Heterochromatin protein 1 homolog gamma; HECH; HP1 gamma homolog
    Approved Symbol:
    CBX3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05130 Entrez Gene ID: 11335 OMIM ID: 604477 Swissprot Accession: A4D177; Q13185;