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Description for Protein CHRM4

cholinergic receptor, muscarinic 4
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04132
    KEGG - Pathway(s):
    hsa04080; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acetylcholine receptor, muscarinic 4
    Approved Symbol:
    CHRM4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amitriptyline(db);
  • Aripiprazole(db);
  • Atropine(db);
  • Benzquinamide(db);
  • Brompheniramine(db);
  • Chlorprothixene(db);
  • Clozapine(db);
  • Cryptenamine(db);
  • Darifenacin(db);
  • Desipramine(db);
  • Doxepin(db);
  • Fesoterodine(db);
  • Homatropine Methylbromide(db);
  • Hyoscyamine(db);
  • Imipramine(db);
  • Isopropamide(db);
  • Maprotiline(db);
  • Methotrimeprazine(db);
  • Metixene(db);
  • Nicardipine(db);
  • Nortriptyline(db);
  • Olanzapine(db);
  • Paroxetine(db);
  • Procyclidine(db);
  • Promazine(db);
  • Promethazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Scopolamine(db);
  • Solifenacin(db);
  • Tolterodine(db);
  • Trihexyphenidyl(db);
  • Tropicamide(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00330 Entrez Gene ID: 1132 OMIM ID: 118495 Swissprot Accession: P08173;