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Description for Protein PARK7

Parkinson disease (autosomal recessive, early onset) 7
13 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(microparticles: 1; platelet: 7; secretome: 1)
Summary:
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K05687
KEGG - Pathway(s):
hsa05012
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
DJ1; RNA binding protein regulatory subunit
Approved Symbol:
PARK7
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Double Oxidized Cysteine(db)

    Associated Genetic Diseases:

  • Amyotrophic lateral sclerosis-parkinsonism/dementia complex 2(Pd);
  • Parkinson disease 7, autosomal recessive early-onset(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03961 Entrez Gene ID: 11315 OMIM ID: 602533 Swissprot Accession: Q99497;