Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CHRM2

cholinergic receptor, muscarinic 2
11 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04130
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FLJ43243; Muscarinic M2 receptor; M2 muscarinic acetylcholine receptor; Muscarinic acetylcholine receptor M2; HM2; Acetylcholine receptor, muscarinic, 2
    Approved Symbol:
    CHRM2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amitriptyline(db);
  • Anisotropine Methylbromide(db);
  • Aripiprazole(db);
  • Atropine(db);
  • Benzquinamide(db);
  • Bethanechol(db);
  • Brompheniramine(db);
  • Carbachol(db);
  • Chlorprothixene(db);
  • Clozapine(db);
  • Cocaine(db);
  • Cryptenamine(db);
  • Cyproheptadine(db);
  • Darifenacin(db);
  • Desipramine(db);
  • Dicyclomine(db);
  • Dimethindene(db);
  • Diphenidol(db);
  • Disopyramide(db);
  • Doxacurium chloride(db);
  • Doxepin(db);
  • Ethopropazine(db);
  • Fesoterodine(db);
  • Flavoxate(db);
  • Gallamine Triethiodide(db);
  • Homatropine Methylbromide(db);
  • Hyoscyamine(db);
  • Imipramine(db);
  • Ipratropium bromide(db);
  • Maprotiline(db);
  • Methotrimeprazine(db);
  • Methylscopolamine(db);
  • Metixene(db);
  • Metocurine(db);
  • Mivacurium(db);
  • Nicardipine(db);
  • Nortriptyline(db);
  • Olanzapine(db);
  • Oxybutynin(db);
  • Oxyphencyclimine(db);
  • Pancuronium(db);
  • Paroxetine(db);
  • Pilocarpine(db);
  • Pipecuronium(db);
  • Procyclidine(db);
  • Promazine(db);
  • Promethazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Rocuronium(db);
  • Scopolamine(db);
  • Solifenacin(db);
  • Succinylcholine(db);
  • Tiotropium(db);
  • Tolterodine(db);
  • Tridihexethyl(db);
  • Triflupromazine(db);
  • Trihexyphenidyl(db);
  • Tropicamide(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    00328_10(7)
  • Isoform 9 : 0
  • Isoform 8 : 7
  • Isoform 7 : 7
  • Isoform 6 : 7
  • Isoform 5 : 7
  • Isoform 4 : 7
  • Isoform 3 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00328 Entrez Gene ID: 1129 OMIM ID: 118493 Swissprot Accession: P08172; Q86SJ1; Q6SL59;