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Description for Protein PNKP

polynucleotide kinase 3'-phosphatase
20 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay. (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • FHA: Forkhead associated domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.78; 3.1.3.32
    KEGG - Orthology:
    K08073
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Polynucleotide kinase; PNK; DNA kinase
    Approved Symbol:
    PNKP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09284 Entrez Gene ID: 11284 OMIM ID: 605610 Swissprot Accession: Q96T60;