Summary:
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K00738
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KEGG - Pathway(s):
hsa00510; hsa01100
(The yellow boxes represents platelet proteins) |
Nomenclature / Alternative Names:
GNT IVB; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; Alpha-1,3-mannosyl-glycoprotein; Mannosyl alpha-1,3-glycoprotein; GNT-IV; Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B; Alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B isoform 1; Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B isoform 2
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Approved Symbol:
| (De-) Phosphorylations:
| Total (de-) phosphorylation sites: 0 |
| No human (de-) phosphorylation sites; | No platelet phosphorylation sites |
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
None Available
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 2 : 1
Isoform 1 : 0
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