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Description for Protein IRAK3

interleukin-1 receptor-associated kinase 3
6 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04732
    KEGG - Pathway(s):
    hsa04210; hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Interleukin 1 receptor associated kinase M; IRAKM; Interleukin 1 receptor associated kinase 3
    Approved Symbol:
    IRAK3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05123 Entrez Gene ID: 11213 OMIM ID: 604459 Swissprot Accession: Q9Y616; B4DQ57;