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Description for Protein CHEK2

CHK2 checkpoint homolog (S. pombe)
41 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FHA: Forkhead associated domain
  • NLS: Nuclear localization signal
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K06641
    KEGG - Pathway(s):
    hsa04110; hsa04115
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RAD53; Checkpoint kinase 2; CDS1; RP11-436C9.1; CHK2; HuCds1; LFS2; PP1425; OTTHUMP00000028871; Checkpoint-like protein CHK2; Protein kinase CHK2; Serine/threonine-protein kinase CHK2; bA444G7; EC 2.7.1.37; Protein kinase CHK2 isoform a; Protein kinase CHK2 isoform c; Protein kinase CHK2 isoform b
    Approved Symbol:
    CHEK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 67
    Human (de-) phosphorylation sites: 67; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 18
    Human phosphorylation targets: 18; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Breast cancer, susceptibility to(Pd);
  • Li-Fraumeni syndrome 2(Pd);
  • Osteosarcoma, somatic(Pd);
  • Prostate cancer, somatic(Pd);
  • Prostate cancer, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05084 Entrez Gene ID: 11200 OMIM ID: 604373 Swissprot Accession: O96017;