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Description for Protein ADCY6

adenylate cyclase 6
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; phosphoproteome: 1; platelet: 2; undefined: 1)
Summary:
This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • GuCyclase: Adenylyl-/guanylyl cyclase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.6.1.1
    KEGG - Orthology:
    K08046
    KEGG - Pathway(s):
    hsa00230; hsa04062; hsa04114; hsa04270; hsa04540; hsa04742; hsa04912; hsa04914; hsa04916; hsa04962; hsa04970; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AC6; KIAA0422; ATP pyrophosphate lyase; Ca(2+) inhibitable adenylyl cyclase; Adenylate cyclase, type VI; Adenylate cyclase 6 isoform a; Adenylate cyclase 6 isoform b
    Approved Symbol:
    ADCY6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    02621_2(11)
    02621_1(12)
    Additional Identifiers:

    HPRD: 02621 Entrez Gene ID: 112 OMIM ID: 600294 Swissprot Accession: O43306;