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Description for Protein RASSF1

Ras association (RalGDS/AF-6) domain family member 1
28 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RA: Ras association (RalGDS/AF-6) domain
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09850
    KEGG - Pathway(s):
    hsa05200; hsa05219; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RASSF1A; Tumor suppressor protein RDA32; Pancreas specific ras association domain family 1 protein; Cardiac specific ras association domain family 1 protein; 123F2; RDA32; NORE2A; REH3P21; Ras association, RalGDS/AF-6, domain family 1; Ras association domain family 1 isoform A; Ras association domain family 1 isoform B; Ras association domain family 1 isoform C; Ras association domain family 1 isoform D
    Approved Symbol:
    RASSF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 36
    Human (de-) phosphorylation sites: 36; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05470 Entrez Gene ID: 11186 OMIM ID: 605082 Swissprot Accession: Q9NS23; Q5TZT2;