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Description for Protein MAP4K5

mitogen-activated protein kinase kinase kinase kinase 5
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CNH: Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08833
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MAPKKKK5; Kinase homologous to SPS1/STE20; KHS; KHS1; GCKR; EC 2.7.1.37; MAPK/ERK kinase kinase kinase 5; MEKKK 5; MEK kinase kinase 5
    Approved Symbol:
    MAP4K5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05374 Entrez Gene ID: 11183 OMIM ID: 604923 Swissprot Accession: Q9Y4K4;