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Description for Protein CHD4

chromodomain helicase DNA binding protein 4
20 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HELIC: helicase superfamily c-terminal domain
  • RING: Ring finger
  • PHD: PHD zinc finger
  • CHROMO: Chromatin organization modifier domain
  • DEXDc: DEAD-like helicases superfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K11643
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Mi2 beta
    Approved Symbol:
    CHD4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 95
    Human (de-) phosphorylation sites: 95; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04472 Entrez Gene ID: 1108 OMIM ID: 603277 Swissprot Accession: B3KY63; Q14839; Q05CG6;