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Description for Protein CHD3

chromodomain helicase DNA binding protein 3
83 total interacting proteins; 33 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HELIC: helicase superfamily c-terminal domain
  • CC: Coiled Coil
  • PHD: PHD zinc finger
  • CHROMO: Chromatin organization modifier domain
  • DEXDc: DEAD-like helicases superfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K11642
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Chromodomain helicase DNA binding protein 3 isoform 1; Chromodomain helicase DNA binding protein 3 isoform 2; Mi-2a; Mi2-alpha; ZFH; Zinc finger helicase; Mi-2 autoantigen 240 kDa protein; Zinc-finger helicase (Snf2-like)
    Approved Symbol:
    CHD3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 39
    Human (de-) phosphorylation sites: 39; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09071 Entrez Gene ID: 1107 OMIM ID: 602120 Swissprot Accession: Q2TAZ1; B3KWV4; Q12873;