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Description for Protein UBE2C

ubiquitin-conjugating enzyme E2C
11 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBC: Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K06688
    KEGG - Pathway(s):
    hsa04120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ubiquitin conjugating enzyme UBCH10; UBCH10; Ubiqitin protein ligase C; Ubiqitin carrier protein C; Ubiquitin carrier protein E2 C; Ubiquitin conjugating enzyme E2C isoform 3; Ubiquitin conjugating enzyme E2C isoform 5; Ubiquitin conjugating enzyme E2C isoform 4; Cyclin selective ubiquitin carrier protein; Mitotic specific ubiquitin conjugating enzyme; Ubiquitin conjugating enzyme E2C isoform 2; EC 6.3.2.19; Ubiquitin conjugating enzyme E2C isoform 1
    Approved Symbol:
    UBE2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05717 Entrez Gene ID: 11065 OMIM ID: 605574 Swissprot Accession: A6NP33; A6NKY3; O00762;