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Description for Protein DSTN

destrin (actin depolymerizing factor)
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/2)
(membrane: 1; microparticles: 1; platelet: 6; undefined: 1)
Summary:
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ADF: Actin depolymerisation factor/cofilin -like domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10363
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Actin depolymerizing factor; ADF; ACTDP; bA462D18.2; DSN; Destrin isoform a; Destrin isoform b
    Approved Symbol:
    DSTN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Lauryl Dimethylamine-N-Oxide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16446 Entrez Gene ID: 11034 OMIM ID: 609114 Swissprot Accession: B4DYA6; P60981;