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Description for Protein COPS6

COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
121 total interacting proteins; 54 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 4)
Summary:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K12179
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
COP9 signalosome subunit 6; COP9 subunit 6; H_NH0506M12.12; MOV34 homolog; COP9 signalosome complex subunit 6; Signalosome subunit 6; SGN6; JAB1-containing signalosome subunit 6; Vpr interacting protein; hVIP; Human Vpr Interacting Protein; CSN6
Approved Symbol:
COPS6
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16735 Entrez Gene ID: 10980 OMIM ID: - Swissprot Accession: Q7L5N1;