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Description for Protein YWHAQ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
134 total interacting proteins; 57 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/2)
(membrane: 1; microparticles: 1; platelet: 5; secretome: 1; undefined: 1)
Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K06630
KEGG - Pathway(s):
hsa04110; hsa04114; hsa04722; hsa05130
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 protein T-cell; HS1 protein; HS1; 1C5; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Approved Symbol:
YWHAQ
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00886 Entrez Gene ID: 10971 OMIM ID: 609009 Swissprot Accession: P27348;