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Description for Protein POP1

processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
10 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.26.5
    KEGG - Orthology:
    K01164
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Processing of precursor RNAs; KIAA0061; MGC17365; Processing of precursor 1, Ribonuclease P/MRP subunit; Ribonuclease P/MRP protein subunit
    Approved Symbol:
    POP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03923 Entrez Gene ID: 10940 OMIM ID: 602486 Swissprot Accession: Q99575; Q96F88;