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Description for Protein MORF4

mortality factor 4
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • HLH: helix loop helix domain
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11339
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Transcription factor-like protein MORF4; Cellular senescence-related protein 1; Senescence-related cellular 1; Cellular senescence 1; Cell senescence-related gene, complementation group B; CSR; SEN; CSRB; SEN1
    Approved Symbol:
    MORF4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15916 Entrez Gene ID: 10934 OMIM ID: 116960 Swissprot Accession: Q9Y690;