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Description for Protein COPS8

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
19 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 7)
Summary:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K12181
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
MGC43256; Signalosome subunit 8; COP9 signalosome subunit 8 isoform 1; COP9 signalosome subunit 8 isoform 2; COP9; CSN8; SGN8; MGC1297; COP9 signalosome subunit 8 Signalosome subunit 8; JAB1-containing signalosome subunit 8
Approved Symbol:
COPS8
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16737 Entrez Gene ID: 10920 OMIM ID: - Swissprot Accession: A8K1H6; Q99627; Q53QS9;