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Description for Protein EHMT2

euchromatic histone-lysine N-methyltransferase 2
33 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SET: SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  • CC: Coiled Coil
  • NLS: Nuclear localization signal
  • ANK: ankyrin repeats
  • PreSET: N-terminal to some SET domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.43
    KEGG - Orthology:
    K11420
    KEGG - Pathway(s):
    hsa00310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Euchromatic histone lysine N methyltransferase 2; BAT8; C6orf30; Chromosome 6 open reading frame 30; EC 2.1.1.43; G9a protein; HLA B associated transcript 8 isoform a; HLA B associated transcript 8; NG36; G9A; Ankyrin repeat containing protein; NG36 protein; Histone lysine N methyltransferase H3 lysine 9 specific 3; Histone H3 K9 methyltransferase 3; H3 K9 HMTase 3; HLA B associated transcript 8 isoform b
    Approved Symbol:
    EHMT2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 29
    Human (de-) phosphorylation sites: 29; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06854 Entrez Gene ID: 10919 OMIM ID: 604599 Swissprot Accession: Q96KQ7;