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Description for Protein MAGED2

melanoma antigen family D, 2
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; phosphoproteome: 1; platelet: 2; secretome: 1; undefined: 1)
Summary:
This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MAGE: melanoma antigen-encoding gene family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Hepatocellular carcinoma associated protein JCL 1; JCL 1; Melanoma antigen, family D 2; BCG1; Breast cancer associated gene 1; Hepatocellular carcinoma associated protein; Hepatocellular carcinoma associated protein HCA10; Melanoma associated antigen D2; 11B6; MAGED2 antigen; MAGED; MGC8386; HCA10
    Approved Symbol:
    MAGED2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; Platelet phosphorylation sites: 4
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06630 Entrez Gene ID: 10916 OMIM ID: 300470 Swissprot Accession: Q9UNF1;