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Description for Protein MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IGC2: Immunoglobulin C-2 Type
  • Ig_LIKE: Immunoglobulin like
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.-
    KEGG - Orthology:
    K07369
    KEGG - Pathway(s):
    hsa04660; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MLT; Paracaspase; Caspase like protein; MALT associated translocation; MALT lymphoma associated translocation; Mucosa associated lymphoid tissue lymphoma translocation gene 1; MLT1; DKFZp434L132; EC 3.4.22.; Mucosa associated lymphoid tissue lymphoma translocation protein 1 isoform a; Mucosa associated lymphoid tissue lymphoma translocation protein 1 isoform b
    Approved Symbol:
    MALT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06892 Entrez Gene ID: 10892 OMIM ID: 604860 Swissprot Accession: Q9UDY8;