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Description for Protein ME3

malic enzyme 3, NADP(+)-dependent, mitochondrial
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.40
KEGG - Orthology:
K00029
KEGG - Pathway(s):
hsa00620; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
NADP-ME; Malate dehydrogenase; Mitochondrial NADP(+)-dependent malic enzyme 3; Pyruvic-malic carboxylase; EC 1.1.1.40; Malic enzyme 3; Malic enzyme 3, NADP(+)-dependent, mitochondrial
Approved Symbol:
ME3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Tartronate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06862 Entrez Gene ID: 10873 OMIM ID: 604626 Swissprot Accession: Q16798; Q8TBJ0; B2R995;