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Description for Protein ADAM28

ADAM metallopeptidase domain 28
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • REP: Replication protein
  • ACR: ADAM Cysteine-Rich Domain
  • EGF: Epidermal growth factor-like domain.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.-
    KEGG - Orthology:
    K08614
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MDCL; MDC Lm; MDC Ls; A disintegrin and metalloproteinase domain 28; Metalloproteinase like disintegrin like and cysteine rich protein L; eMDCII; Metalloproteinase like disintegrin like and cysteine rich protein lymphocyte expressed; ADAM metallopeptidase domain 28 isoform 1 preproprotein; ADAM23; EC 3.4.24.-; ADAM metallopeptidase domain 28 isoform 3 preproprotein
    Approved Symbol:
    ADAM28
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE(db);
  • 2-(Thiomethylene)-4-Methylpentanoic Acid(db);
  • Batimastat(db);
  • Furoyl-Leucine(db);
  • GM6001(db);
  • N-[(Furan-2-Yl)Carbonyl]-(S)-Leucyl-(R)-[1-Amino-2(1h-Indol-3-Yl)Ethyl]-Phosphonic Acid(db);
  • Pyroglutamic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 08391 Entrez Gene ID: 10863 OMIM ID: 606188 Swissprot Accession: Q9UKQ2;