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Description for Protein RUVBL2

RuvB-like 2 (E. coli)
93 total interacting proteins; 42 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/2)
(microparticles: 1; platelet: 3; secretome: 1; undefined: 1)
Summary:
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K11338
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ECP51; TIP48; CGI46; TIP49B; Reptin52; TAP54 beta; Repressing pontin 52; 48 kDa TBP interacting protein; TIP60 associated protein 54 beta; Erythrocyte cytosolic protein, 51 KD; 48 kDa TATA box binding protein interacting protein
    Approved Symbol:
    RUVBL2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16070 Entrez Gene ID: 10856 OMIM ID: 604788 Swissprot Accession: Q9Y230;