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Description for Protein HPSE

heparanase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 12; secretome: 1; undefined: 2)
Summary:
Heparan sulfate proteoglycans (HSPGs) are major components of the basement membrane and extracellular matrix. Heparanases, like HSPE, are endoglycosidases that cleave the heparan sulfate side chain of HSPGs to permit the remodeling of the extracellular matrix for cell movement or the release of bioactive molecules from the extracellular matrix or cell surface (summary by McKenzie et al., 2000 [PubMed 11027606]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.-
    KEGG - Orthology:
    K07964
    KEGG - Pathway(s):
    hsa00531; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HSE1; HPA
    Approved Symbol:
    HPSE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Heparin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05286 Entrez Gene ID: 10855 OMIM ID: 604724 Swissprot Accession: Q9Y251; C7F7I3;