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Description for Protein PDE10A

phosphodiesterase 10A
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate (Fujishige et al., 2000 [PubMed 10998054]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • GAF: Domain present in phytochromes and cGMP-specific phosphodiesterases.
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.17
    KEGG - Orthology:
    K01120
    KEGG - Pathway(s):
    hsa00230
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HSPDE10A; cAMP and cAMP-inhibited cGMP 3`,5`-cyclic phosphodiesterase 10A; EC 3.1.4.17
    Approved Symbol:
    PDE10A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE(db);
  • 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline(db);
  • 2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline(db);
  • 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline(db);
  • 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole(db);
  • 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE(db);
  • 6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE(db);
  • Dipyridamole(db);
  • Papaverine(db);
  • Tofisopam(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 17828 Entrez Gene ID: 10846 OMIM ID: 610652 Swissprot Accession: Q9Y233; Q9ULW9;