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Description for Protein FTCD

formiminotransferase cyclodeaminase
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.2.5; 4.3.1.4
KEGG - Orthology:
K00603
K01746
KEGG - Pathway(s):
hsa00340; hsa00670; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glutamate formimidoyltransferase; LCHC1; Formimidoyltransferase cyclodeaminase
Approved Symbol:
FTCD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-Formyl-5,6,7,8-Tetrahydrofolate(db);
  • L-Glutamic Acid(db);
  • Pyridoxal Phosphate(db);
  • Tetrahydrofolic acid(db)

    Associated Genetic Diseases:

  • Glutamate formiminotransferase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08430 Entrez Gene ID: 10841 OMIM ID: 606806 Swissprot Accession: O95954;