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Description for Protein NEU3

sialidase 3 (membrane sialidase)
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.18
    KEGG - Orthology:
    K12357
    KEGG - Pathway(s):
    hsa00511; hsa00600
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sialidase 3; Sial3; Sialidase, membrane; N acetyl alpha neuraminidase 3; Ganglioside sialidase
    Approved Symbol:
    NEU3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05215 Entrez Gene ID: 10825 OMIM ID: 604617 Swissprot Accession: A8K327; Q9UQ49;