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Description for Protein MTHFD2

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.5.1.15; 3.5.4.9
    KEGG - Orthology:
    K13403
    KEGG - Pathway(s):
    hsa00630; hsa00670; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Methylene tetra hydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase, NAD(+) dependant; NAD dependent methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase; NMDMC; Methylene tetrahydrofolate dehydrogenase 2 isoform B; Methylene tetrahydrofolate dehydrogenase 2 isoform A precursor
    Approved Symbol:
    MTHFD2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db);
  • Tetrahydrofolic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05351 Entrez Gene ID: 10797 OMIM ID: 604887 Swissprot Accession: P13995;