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Description for Protein IQGAP2

IQ motif containing GTPase activating protein 2
10 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/3)
(membrane: 2; microparticles: 1; platelet: 12; secretome: 2; undefined: 2)
Summary:
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • CH: Calponin homology domain
  • WW: Domain with 2 conserved Trp (W) residues
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • RASGAP: GTPase-activator protein for Ras-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05767
    KEGG - Pathway(s):
    hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IQ motif containing GTPase activating protein 2; Ras GTPase-activating-like protein IQGAP2
    Approved Symbol:
    IQGAP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09253 Entrez Gene ID: 10788 OMIM ID: 605401 Swissprot Accession: Q13576; Q59HA3;