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Description for Protein TRAF3IP2

TRAF3 interacting protein 2
12 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
None Available
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
ACT1; Chromosome 6 open reading frame 4; Chromosome 6 open reading frame 6; Adapter protein CIKS; C6orf4; C6orf5; C6orf6; MGC3581; DKFZP586G0522; TRAF3 interacting protein 2; NFkB-activating protein ACT1; Connection to IKK and SAPK/JNK; TRAF3 interacting protein 2 isoform 1; Chromosome 6 open reading frame 5; Nuclear factor NF-kappa-B activator 1; TRAF3 interacting protein 2 isoform 2
Approved Symbol:
TRAF3IP2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06129 Entrez Gene ID: 10758 OMIM ID: 607043 Swissprot Accession: O43734; Q7Z6Q1; Q7Z6Q2;