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Description for Protein NFAT5

nuclear factor of activated T-cells 5, tonicity-responsive
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • IPT: ig-like, plexins, transcription factors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04446
    KEGG - Pathway(s):
    hsa04310; hsa04360; hsa04370; hsa04650; hsa04660; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TonE binding protein; NFATL1; TONEBP; Glutamine rich protein H65; NFAT like protein 1; OREBP; KIAA0827; Nuclear factor of activated T-cells 5 isoform a; NFATZ; Tonicity-responsive enhancer-binding protein; T cell transcription factor NFAT5; Nuclear factor of activated T-cells 5 isoform b; Nuclear factor of activated T-cells 5 isoform c
    Approved Symbol:
    NFAT5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 23
    Human (de-) phosphorylation sites: 23; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05272 Entrez Gene ID: 10725 OMIM ID: 604708 Swissprot Accession: Q7LA65; O94916; Q96QH3;