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Description for Protein CFL1

cofilin 1 (non-muscle)
30 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 13/3)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 9; secretome: 1; undefined: 2)
Summary:
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • ADF: Actin depolymerisation factor/cofilin -like domains
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05765
    KEGG - Pathway(s):
    hsa04360; hsa04666; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CFL; Cofilin, non muscle; 18 kDa phosphoprotein; p18
    Approved Symbol:
    CFL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Lauryl Dimethylamine-N-Oxide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03261 Entrez Gene ID: 1072 OMIM ID: 601442 Swissprot Accession: P23528;