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Description for Protein TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TNF: Tumour necrosis factor family.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05476
    KEGG - Pathway(s):
    hsa04060; hsa04672
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BAFF; B lymphocyte stimulator; BLYS; B cell activating factor; TALL1; THANK; TNFSF20; ZTNF4; DTL precursor; ApoL related ligand TALL-1; Dendritic cell derived TNF like molecule; Tumor necrosis factor-like protein ZTNF4
    Approved Symbol:
    TNFSF13B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,4-Diethylene Dioxide(db);
  • Citric Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04914 Entrez Gene ID: 10673 OMIM ID: 603969 Swissprot Accession: Q7Z5J2; Q9Y275; Q6FHD6;