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Description for Protein CES1

carboxylesterase 1
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.1
    KEGG - Orthology:
    K01044
    KEGG - Pathway(s):
    hsa00983; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TGH; ACAT; CES2; MGC117365; Triacylglycerol hydrolase; Carboxylesterase 1 isoform b precursor; Carboxylesterase 1 isoform a precursor; Carboxylesterase 1 isoform c precursor; Acyl coenzyme A cholesterol acyltransferase; Monocyte/macrophage serine esterase 1; Monocyte/macrophage serine esterase; Alpha naphthylacetate esterase; Brain carboxylesterase hBr1; Cholesteryl ester hydrolase; Liver carboxylesterase; Carboxylesterase liver; Alveolar esterase; Serine esterase 1; Acid esterase; Egasyn; HMSE1; HMSE; ANAE; SES1; CEH; HU1; EC 3.1.1.1
    Approved Symbol:
    CES1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE(db);
  • (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL(db);
  • 4-Piperidino-Piperidine(db);
  • Alpha-D-Mannose(db);
  • Cholic Acid(db);
  • Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester(db);
  • N-Methylnaloxonium(db);
  • O-Sialic Acid(db);
  • Oseltamivir(db);
  • Thenoyltrifluoroacetone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00268 Entrez Gene ID: 1066 OMIM ID: 114835 Swissprot Accession: P23141;