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Description for Protein CAMKK2

calcium/calmodulin-dependent protein kinase kinase 2, beta
23 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.17
    KEGG - Orthology:
    K07359
    KEGG - Pathway(s):
    hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EC 2.7.1.37; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-kinase kinase beta; CaM-KK beta; CAMKKB; KIAA0787; MGC15254; Calcium/calmodulin-dependent protein kinase beta; CAMKK beta protein; Calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 1; Calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 2; Calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 4; Calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 5; Calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 6; Calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 3; CaMKKbeta 1; CaMKK beta2
    Approved Symbol:
    CAMKK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 3
    Human phosphorylation targets: 3; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06467 Entrez Gene ID: 10645 OMIM ID: - Swissprot Accession: Q96RR4;