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Description for Protein USP16

ubiquitin specific peptidase 16
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • UCH: Ubiquitin carboxyl-terminal hydrolase
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.2.15
    KEGG - Orthology:
    K11844
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Ubiquitin specific protease 16 isoform a; Ubiquitin specific protease 16 isoform b; EC 3.1.2.15; Ubiquitin specific processing protease 16; Deubiquitinating enzyme 16; Ubiquitin processing protease UBP M; UBPM; Ubiquitin carboxyl terminal hydrolase 16; Ubiquitin thiolesterase 16; Ubiquitin specific peptidase 16
    Approved Symbol:
    USP16
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06881 Entrez Gene ID: 10600 OMIM ID: 604735 Swissprot Accession: Q9Y5T5;