Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein PRPF8

PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
16 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K12856
KEGG - Pathway(s):
hsa03040
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PRP8; PRPC8; U5 snRNP SPECIFIC PROTEIN, 220KD; HPRP8; RP13
Approved Symbol:
PRPF8
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 21
Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Retinitis pigmentosa 13(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06295 Entrez Gene ID: 10594 OMIM ID: 607300 Swissprot Accession: Q6P2Q9;