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Description for Protein CEL

carboxyl ester lipase (bile salt-stimulated lipase)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.13; 3.1.1.3
    KEGG - Orthology:
    K12298
    KEGG - Pathway(s):
    hsa00100; hsa00561; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Carboxyl ester hydrolase; Cholesterol esterase; Lysophospholipase; Bile salt stimulated lipase; Bile salt dependent lipase, oncofetal isoform; Fetoacinar pancreatic protein; Carboxyl ester lipase like; Sterol esterase; Bile salt activated lipase; Pancreatic lysophospholipase; BAL; BSSL; BSDL; FAPP; FAP; CELL; LIPA; CEase
    Approved Symbol:
    CEL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Taurocholic Acid(db)

    Associated Genetic Diseases:

  • Maturity-onset diabetes of the young, type VIII, with exocrine dysfunction(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07509 Entrez Gene ID: 1056 OMIM ID: 114840 Swissprot Accession: P19835;