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Description for Protein AGPAT2

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.51
    KEGG - Orthology:
    K13509
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LPAAT-BETA; Lysophosphatidic acid acyltransferase-beta BSCL1; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; EC 2.3.1.51; 1-acylglycerol-3-phosphate O-acyltransferase 2 isoform a; 1-acylglycerol-3-phosphate O-acyltransferase 2 isoform b; BSCL; BSCL1; LPAAB; 1-AGPAT2; 1-AGP acyltransferase 2; Berardinelli-Seip congenital lipodystrophy; Lysophosphatidic acid acyltransferase-beta
    Approved Symbol:
    AGPAT2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Lipodystrophy, congenital generalized, type 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 3
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 04373 Entrez Gene ID: 10555 OMIM ID: 603100 Swissprot Accession: O15120;