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Description for Protein AGPAT1

1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(membrane: 1; platelet: 1)
Summary:
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.51
    KEGG - Orthology:
    K13509
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    1 AGP acyltransferase 1; LPAATA; Lysophospholipid acyltransferase; 1 AGPAT1; 1 acylglycerol 3 phosphate O acyltransferase 1; G15; LPAAT alpha; EC 2.3.1.51; G15 protein
    Approved Symbol:
    AGPAT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 3
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 04372 Entrez Gene ID: 10554 OMIM ID: 603099 Swissprot Accession: Q99943;