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Description for Protein KAT5

K(lysine) acetyltransferase 5
96 total interacting proteins; 35 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C2HC: zinc finger
  • HAT: HAT (Half-A-TPR) repeats
  • CHROMO: Chromatin organization modifier domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.48
    KEGG - Orthology:
    K11304
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    cPLA2 interacting protein; TIP60; PLIP; 60 kDa Tat interactive protein; ESA1; HIV-1 Tat interactive protein, 60kDa; Tat interactive protein (60kD); cPLA2; HTATIP1; Histone acetyltransferase HTATIP; EC 2.3.1.48; HIV-1 Tat interactive protein, 60kDa isoform 1; HIV-1 Tat interactive protein, 60kDa isoform 2; HIV-1 Tat interactive protein, 60kDa isoform 3; PLA2-interacting protein
    Approved Symbol:
    KAT5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Coenzyme A(db);
  • Cysteine Sulfenic Acid(db);
  • S-Acetyl-Cysteine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03245 Entrez Gene ID: 10524 OMIM ID: 601409 Swissprot Accession: C9JL99; Q92993;