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Description for Protein DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
27 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • HELIC: helicase superfamily c-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K13178
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    RP3-434P1.1; DKFZp761H2016; OTTHUMP00000028920; Probable RNA-dependent helicase p72; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD); EC 3.6.1.-; DEAD-box protein p72; RNA-dependent helicase p72; Probable ATP-dependent helicase DDX17; DEAD box polypeptide 17 isoform p82; DEAD box polypeptide 17 isoform 2; RH70; RNA helicase, 70-KD; p72; Dead/H box 17; DEAD box polypeptide 17; DEAD box polypeptide 17 isoform 3; DEAD box polypeptide 17 isoform 4
    Approved Symbol:
    DDX17
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 28
    Human (de-) phosphorylation sites: 28; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10532 Entrez Gene ID: 10521 OMIM ID: 608469 Swissprot Accession: Q92841; Q59F66; Q9UQL5;