Summary:
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM] (PubMed Links)
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| Domains and Motifs:
PAS: PAS domain
HLH: helix loop helix domain
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Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K11255
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KEGG - Pathway(s):
None Available
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Nomenclature / Alternative Names:
Nuclear receptor coactivator 2; Transcriptional intermediary factor 2; Glucocorticoid receptor interacting protein 1; GRIP1
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID(db);
(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL(db);
(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL(db);
17-METHYL-17-ALPHA-DIHYDROEQUILENIN(db);
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE(db);
2-chloro-5-nitro-N-phenylbenzamide(db);
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID(db);
3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL(db);
3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL(db);
4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol(db);
4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL(db);
4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL(db);
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL(db);
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL(db);
4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL(db);
4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol(db);
B-Octylglucoside(db);
DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE(db);
dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate(db);
Genistein(db);
Methyltrienolone(db);
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE(db);
RALOXIFENE CORE(db);
tributylstannanyl(db)
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
| Additional Identifiers:
| HPRD: | 09066 | | Entrez Gene ID: | 10499 | | OMIM ID: | 601993 | | Swissprot Accession: | Q15596; | | |
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