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Description for Protein TAB1

TGF-beta activated kinase 1/MAP3K7 binding protein 1
14 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2C: Serine/threonine phosphatases, family 2C, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04403
    KEGG - Pathway(s):
    hsa04010; hsa04620; hsa04621; hsa05140
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TAB1; TAK1 binding protein 1; MGC57664; Transforming growth factor beta-activated kinase-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alpha; Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform beta
    Approved Symbol:
    TAB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04012 Entrez Gene ID: 10454 OMIM ID: 602615 Swissprot Accession: A8K6K3; Q15750; Q8IZW2;