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Description for Protein VAV3

vav 3 guanine nucleotide exchange factor
16 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • CH: Calponin homology domain
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05730
    KEGG - Pathway(s):
    hsa04062; hsa04510; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04670; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    VAV3 oncogene; Vav 3 oncogene isoform 2; Vav 3 oncogene isoform 1
    Approved Symbol:
    VAV3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05706 Entrez Gene ID: 10451 OMIM ID: 605541 Swissprot Accession: Q9UKW4; O60498; B4E232;