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Description for Protein PPIE

peptidylprolyl isomerase E (cyclophilin E)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.2.1.8
    KEGG - Orthology:
    K09564
    KEGG - Pathway(s):
    hsa03040
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Peptidyl prolyl cis trans isomerase E; Cyclophilin 33kD; CYP33; Cyclophilin E; Rotamase E; PPIase E; Cyclophilin 33; EC 5.2.1.8; Peptidylprolyl isomerase E isoform 1; Peptidylprolyl isomerase E isoform 2; Peptidylprolyl isomerase E isoform 3
    Approved Symbol:
    PPIE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03893 Entrez Gene ID: 10450 OMIM ID: 602435 Swissprot Accession: Q9UNP9;