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Description for Protein WFDC2

WAP four-disulfide core domain 2
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • WAP: Four-disulfide core domains
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    WAP four-disulfide core domain 2 isoform 4 precursor; WAP four-disulfide core domain 2 isoform 5; WAP four-disulfide core domain 2 isoform 2 precursor; HE4; WAP5; dJ461P17.6; Epididymal secretory protein E4; WAP domain containing protein HE4 V4; Major epididymis specific protein E4; Epididymis specific, whey acidic protein type, four disulfide core; Putative protease inhibitor WAP5; WAP four-disulfide core domain 2 isoform 1 precursor
    Approved Symbol:
    WFDC2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 1
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 11684 Entrez Gene ID: 10406 OMIM ID: - Swissprot Accession: Q14508;